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NASHVILLE -- The San Francisco 49ers know how to start a very long road trip in winning style. Colin Kaepernick threw for 199 yards and ran for 68 and a touchdown, helping the 49ers start a two-game road swing by beating the Tennessee Titans 31-17 Sunday. The 49ers (5-2) won their fourth straight before heading to London for a game with winless Jacksonville by jumping to a 17-0 halftime lead. Frank Gore also ran for a pair of 1-yard TDs as San Francisco cruised. "This was a big game, and we were treating it like the biggest game of the season," 49ers coach Jim Harbaugh said. "It was our next game. This was Game 7 for us, and we were treating it like Game 7 for us, and we were treating it like Game 7 of the World Series or Game 7 of the Stanley Cup. Now the next game will be Game 8." Tramaine Brock also intercepted a pass, Justin Smith had two of the 49ers three sacks and Kassim Osgood recovered a muffed punt for a TD. The Titans (3-4) lost their third straight even with Jake Locker starting after missing two games with a sprained right hip and knee. Locker threw for 326 yards, with two TD passes in a fourth-quarter spurt that came up short. Coach Mike Munchak defended the decision to start Locker, saying the quarterback was ready. Locker also ran three times for 29 yards. "We felt comfortable hed be able to protect himself," Munchak said. "I think he showed he could do that." The Titans outgained the 49ers 368-349 in total offence only because of a frantic fourth quarter as they tried to rally. San Francisco still had a big edge in time of possession, holding the ball for more than 35 minutes, including the third quarter when the 49ers played keepaway for more than 11 minutes. Gore capped the opening drive of the third with his second TD for a 24-0 lead. "I dont know how you define midseason form, but we have strung together a few wins and we feel pretty good about what were doing right now," Kaepernick said. Tennessee tried to make it interesting late in a finish that featured plenty of pushing and shoving. Even Harbaugh got an arm caught up in a scrum on the San Francisco sideline after Kaepernick dived in trying to recover what he and the Titans thought was a fumble. "I was just trying to get them apart," Harbaugh said. Locker tossed a short pass to Chris Johnson for a 66-yard TD, pulling Tennessee within 24-10 with 7:07 left, and the Titans forced the 49ers to punt. But Tommie Campbell blocked Darryl Morris into Darius Reynaud, who muffed the punt. Osgood recovered in the end zone for the clinching TD. Locker found former 49ers tight end Delanie Walker on a 26-yard TD with 3:17 left. The Titans were offside on the ensuing onside kick, and the 49ers recovered to run out the clock. The 49ers were in control from the start with plenty of fans on hand, and they took advantage of Tennessees 10 penalties for 100 yards. The most costly came when linebacker Akeem Ayers hit Kaepernick at the knees for an unnecessary roughness flag that wiped out an interception by safety Bernard Pollard. Three plays later, Kaepernick ran 20 yards for a TD and a 10-0 lead. The Titans held Gore to 70 yards rushing on 24 carries, but he got into the end zone twice. They could not stop Kaepernick, who repeatedly kept drives alive in improving to 12-5 as a starter. "He continues to get better every game since hes been playing," Harbaugh said. "He got a game ball last week and I thought he was very effective today both running and throwing. I cant say enough good things about him." Locker hadnt been expected back before Nov. 3, when the Titans visit St. Louis after their bye. Playing with a knee brace, he hit seven of his first 10 passes for 80 yards. His best run was 16-yarder giving the Titans first-and-goal early in the fourth quarter when Locker put his head down diving forward. They wound up settling for a field goal. "We found ways to stall drives out," Locker said. "I didnt think it was really us getting going. Weve got to find ways to do that." But Brock picked off an underthrown ball for the quarterbacks first interception this season. The 49ers quickly converted that into a 1-yard TD run by Gore for a 17-0 lead just before halftime. Notes: Brock now has three interceptions in three games. ... The 49ers now lead this series 8-5. ... The Titans had a video tribute to the late Bum Phillips and a moment of silence before the coin toss. Phillips coached this franchise to two AFC championship game appearances in the late 1970s as the then-Houston Oilers. ... Johnson now has three TD catches of 66 yards or longer and 11 TDs of 66 yards or longer in his career. NMD CS2 Canada . 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After two months of mediocrity, perhaps the Washington Nationals have turned the page. Strasburg struck out 11 in seven innings Wednesday night and the Nationals kept the Philadelphia Phillies bats quiet yet again in an 8-4, rain-interrupted win.San Diego, CA (SportsNetwork.com) - The Arizona Diamondbacks selected catcher Oscar Hernandez of the Tampa Bay Rays organization with the first pick in Major League Baseballs annual Rule 5 Draft on Thursday. Hernandez, 21, had been in the Rays system since signing as a 16-year-old out of Venezuela. He appeared in 94 games for Single-A Bowling Green last season and batted .249 with nine home runs and 63 RBI. He may have put together one of the greatest Venezuelan Summer League seasons anyone will ever see in 2011, hitting .402/.503/.732 with 21 home runs. Hernandez led the league in batting average by 38 points, home runs by 13, slugging percentage by .238 points, total bases by 37 and on-base percentage by 39 points. Hernandez, though, has never come anywhere close to matching those numbers and isnt fully polished behind the plate There were 14 players taken in the major league phase of the draft on Thursday. If those players do not sign with their new team, they must be offered back to their original team, effectively canceling the Rule 5 Draft choice. However, once they spend an entire season on their new teams 25-man roster, their status reverts to normal and they may be optioned or designated for assignment. Of course, several players have succeeded through the Rule 5 Draft in the past, most notably Hall of Famer Roberto Clemente, two-time Cy Young Award winner Johan Santana and 2010 AL MVP Josh Hamilton. Other prominent players selected through the Rule 5 Draaft include pitchers Joakim Soria, Matt Mantei and Antonio Alfonseca, as well as second baseman Dan Uggla and outfielders George Bell, Willy Taveras and Shane Victorino.dddddddddddd. Players who are not currently on their teams 40-man roster are eligible to be taken in this draft, but only after a standard exemption period has elapsed. Also, only teams whose rosters are under the 40-man limit are eligible to participate. A player who is 18 when hes signed can spend five seasons in an organization before he has to be protected. Anyone who is 19 or older must be protected after four years. Once past that time of service, a player must be put on the 40-man roster if that team wants to keep him from becoming eligible for the Rule 5 Draft. MAJOR LEAGUE PHASE 1. Arizona Diamondbacks: C Oscar Hernandez, Rays 2. Colorado Rockies: IF Mark Canha, Marlins (Traded to Oakland) 3. Texas Rangers: OF Delino DeShields Jr., Astros 4. Houston Astros: RHP Jason Garcia, Red Sox (Traded to Baltimore) 5. Minnesota Twins: RHP J.R. Graham, Braves 6. Boston Red Sox: RHP Jandel Gustave, Astros (Traded to Kansas City) 7. Chicago Cubs: SS Taylor Featherston, Rockies (Traded to LA Angels) 8. Philadelphia Phillies: IF David Herrera, Rangers 9. Miami Marlins: LHP Andrew McKirahan, Cubs 10. New York Mets: LHP Sean Gilmartin, Twins 11. Atlanta Braves: RHP Daniel Winkler, Rockies 12. Seattle Mariners: LHP David Rollins, Astros 13. Baltimore Orioles: RHP Logan Verrett, Mets 14. Philadelphia Phillies: LHP Andrew Oliver, Pittsburgh ' ' '